Research Laboratory Technician Intermediate, Ann Arbor

Cardiovascular Research Lab Position

Work under the direction of an investigator in cardiovascular research to achieve the goals of a sponsored project in a laboratory setting. The overall goal of the project is to develop new treatments for patients with heart muscle disorders (primarily hypertrophic, arrhythmogenic, and other types of inherited cardiomyopathy). These disorders are a cause of heart failure, arrhythmias, and sudden death in both children and adults. The lab uses a range of model systems to better understand these conditions and develop treatments. This position will be responsible for managing mouse models of various experimental models of inherited cardiomyopathy, performing experiments using these genetic models, including testing medications and/or gene therapies, performing biochemical assays, genotyping, RNA/DNA extractions, and other molecular biology techniques, and performing phenotypic assays on these models (e.g., histology, functional measurements on heart tissue).Responsibilities

Perform molecular biology assays, including DNA extraction, RNA extraction, genotyping, PCR, gel electrophoresis, biochemical assays, recombinant DNA cloning, and qRT-PCR. Manage a mouse colony consisting of multiple genetic models of cardiomyopathy (multiple strains, crosses, and breeding schemes). Set up breeding cages to maintain mice and generate experimental mice. Stratify mice into randomized groups for medication and/or gene therapy experiments. Monitor and ensure colony health working closely with ULAM. Maintain database for mouse management in Excel with meticulous attention to detail.Administer medications to mice (including by food, water, gastric lavage) for experimental interventions. Track responses of medications across experimental groups. Coordinate procedures on experimental groups, such as echocardiograms, with core phenotyping services. Dissect post-mortem mice to obtain heart and other tissues for biochemical and functional analyses.Routine laboratory maintenance including ordering and restocking, biohazard waste autoclaving and disposal, and dishwashing. Regularly communicate and coordinate with other team members to perform experiments in mouse models. Participate in weekly lab meetings. Required Qualifications

The applicant should have a minimum of a B.S. degree in a biological or related field. 1 year of prior laboratory experience Prior experience with mouse colony management, basic molecular biology techniques, including PCR and genotyping techniques, is required. Excellent organizational skills, perseverance, the ability to keep detailed notes, meticulous attention to details, excellent verbal and written English language skills, and an eagerness to work as an integrated team player which may include teaching rotating students and fellows.Proficiency in Excel for the purpose of mouse colony management is required. The applicant must demonstrate strong motivation and work ethic to master new skills. Why Join Michigan Medicine?

Michigan Medicine is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000 employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world’s most distinguished academic health systems. In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good.What Benefits can you Look Forward to? Excellent medical, dental and vision coverage effective on your very first day 2:1 Match on retirement savings Work Schedule

The work schedule will be standard business hours M-F. Flexible hours for covering on 1-2 half weekend days per month if needed for mouse husbandry/experimental protocols. Work Locations

Location is on-site only (medical research campus). Background Screening

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.Application Deadline

Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended. U-M EEO Statement

The University of Michigan is an equal employment opportunity employer.