Senior Scientist, Protein Engineering & Structural Biology, Rockville, MD

Our biotech client is expanding their world-class Antibody Engineering group and seeking an exceptional scientist with deep expertise in structural biology and protein engineering, with a strong drive to apply structural insight to antibody discovery and optimization.

The ideal candidate will take on the following tasks:

· Leverage cryo-EM, X-ray crystallography, and complementary biophysical techniques to elucidate antibody-antigen interactions, define epitope architecture, and inform structure-guided engineering decisions.

· Apply protein structure/function expertise to challenging drug targets — including membrane proteins and conformational epitopes — translating structural knowledge into actionable engineering hypotheses.

· Partner closely with antibody engineering colleagues to integrate structural data into discovery and optimization campaigns, driving rational lead progression.

· Develop and advance computational and experimental approaches to protein structure prediction, model validation, and structure-based design , including integration of AlphaFold, Rosetta, and molecular dynamics tools.

· Shape intellectual property and advance the field through inventorship and high-impact publications.

· Contribute broad, adaptable skill sets across the antibody engineering platform — bringing a generalist scientific rigor that accelerates innovation beyond any single technical discipline.

The ideal candidate will possess the following qualifications:

· PhD in Structural Biology, Biophysics, Biochemistry, or related field.

· Deep hands-on expertise in cryo-EM and/or X-ray crystallography, with demonstrated application to protein structure/function questions.

· Prior exposure to antibody-based work is a plus but not required — broad scientific adaptability is valued over narrow specialization.

· High-impact publication record preferred.

· Desire to work at the interface of experimental structural biology and antibody development.